TB-500 5mg

TB-500

Synonym: Thymosin Beta-4 (Fragment/Analog)

CAS Number: N/A (varies by form/fragment)

Molecular Formula: Varies (commonly associated with Thymosin Beta-4: C₂₁₂H₃₅₀N₅₆O₇₈S)

Molecular Weight: ~4963.4 g/mol (full-length reference)

Structure: Synthetic peptide corresponding to, or derived from, Thymosin Beta-4, a naturally occurring actin-binding peptide

Overview

TB-500 is a synthetic peptide representing either the full-length Thymosin Beta-4 (43 amino acids) or functional fragments designed to replicate its biological activity. Thymosin Beta-4 is an endogenous peptide widely distributed in mammalian tissues and is involved in cell migration, angiogenesis, and cytoskeletal organization.

TB-500 is utilized in research to study processes related to actin regulation, tissue remodeling, and cellular signaling pathways associated with repair mechanisms.

Mechanism of Action

TB-500 primarily exerts its effects through interaction with actin dynamics and cellular migration pathways:

• Actin Sequestration

  • Binds to G-actin (globular actin)

  • Regulates actin polymerization and cytoskeletal organization

   

• Cell Migration & Differentiation

  • Facilitates cell motility, including endothelial and epithelial cells

  • Supports processes involved in tissue remodeling

   

• Angiogenic Signaling

  • Associated with increased vascular endothelial growth factor (VEGF) expression

  • Promotes formation of new vascular structures in experimental models

   

• Anti-Inflammatory Signaling

  • Modulates cytokine activity and inflammatory response pathways

  • Influences cellular response to injury-related signaling

   

The peptide’s activity is largely non-receptor specific, functioning through intracellular and extracellular signaling modulation.

Pharmacokinetic Characteristics

• Rapid distribution across tissues in experimental models

• Activity influenced by interaction with intracellular actin pools

• Short intrinsic half-life for native forms; synthetic variants may differ

• Cleared via standard proteolytic degradation pathways

Structural Characteristics

TB-500 corresponds to Thymosin Beta-4, a 43-amino acid peptide, or its active regions:

• Contains actin-binding domains critical for function

• Highly conserved sequence across species

• Does not require lipidation for biological activity

• Functional fragments are designed to retain core bioactive regions

Research Applications

TB-500 is studied in experimental settings involving:

• Cytoskeletal dynamics and actin regulation

• Cell migration and differentiation

• Angiogenesis and vascular development

• Inflammatory response modulation

• Tissue remodeling and repair-related signaling

It is commonly utilized in research examining cellular movement and structural protein interactions.

Handling & Stability

• Typically supplied as a lyophilized powder

• Requires reconstitution with a sterile solvent prior to use

• Store at low temperatures (commonly -20°C or below) for long-term stability

• Avoid repeated freeze-thaw cycles

• Stability may vary depending on whether full-length or fragment form is used

Note

This material is intended for laboratory research use only and is not approved for human or veterinary applications.