BPC-157 5mg

BPC-157

Synonym: Body Protection Compound-157

CAS Number: 137525-51-0

Molecular Formula: C₆₂H₉₈N₁₆O₂₂

Molecular Weight: ~1419.5 g/mol

Structure: Synthetic pentadecapeptide (15 amino acids) derived from a partial sequence of human gastric proteins

Overview

BPC-157 is a synthetic peptide consisting of a 15-amino acid sequence derived from a region of a naturally occurring protein found in gastric tissue. It is characterized by high stability in gastric conditions and resistance to enzymatic degradation relative to many short-chain peptides.

The compound has been studied in various experimental models for its interaction with cellular repair mechanisms, angiogenic signaling pathways, and cytoprotective processes.

Mechanism of Action

BPC-157 exhibits a multi-pathway mode of action, with observed interactions across several biological systems:

• Angiogenic Modulation

  • Upregulation of vascular endothelial growth factor (VEGF) signaling

  • Promotion of endothelial cell migration and vessel formation

   

• Nitric Oxide (NO) System Interaction

  • Modulation of nitric oxide synthesis and signaling pathways

  • Potential effects on vascular tone and microcirculation

   

• Cytoprotective Activity

  • Interaction with pathways involved in cell survival and stress response

  • Observed influence on epithelial and endothelial integrity

   

• Extracellular Matrix & Tissue Signaling

  • Involvement in fibroblast activity and collagen-related processes

  • Modulation of signaling relevant to tissue remodeling

   

The peptide’s activity appears to be pleiotropic, involving coordinated effects across vascular, cellular, and signaling systems rather than a single receptor-specific pathway.

Pharmacokinetic Characteristics

• Demonstrates stability in gastric and enzymatic environments

• Low molecular weight relative to larger peptide therapeutics

• Rapid systemic distribution observed in experimental models

• Metabolized via standard peptide degradation pathways

Structural Characteristics

BPC-157 is a linear pentadecapeptide with the sequence:

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Key features include:

• High proportion of proline residues, contributing to structural stability

• Resistance to conformational breakdown in biologically active environments

• No lipidation or large carrier modifications required for activity

Research Applications

BPC-157 is investigated in experimental settings involving:

• Angiogenesis and vascular biology

• Cellular repair and regeneration signaling

• Gastrointestinal system models

• Musculoskeletal and connective tissue research

It is frequently studied for its role in multi-system cytoprotective responses and signaling pathway interactions.

Handling & Stability

• Typically supplied as a lyophilized powder

• Requires reconstitution with a sterile solvent prior to use

• Store at low temperatures (commonly -20°C or below) for long-term stability

• Stable across a range of pH conditions relative to many peptides

• Avoid repeated freeze-thaw cycles

Note

This material is intended for laboratory research use only and is not approved for human or veterinary applications.