Selank

Selank

Synonym: TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro

CAS Number: 129954-34-3

Molecular Formula: C₃₃H₅₇N₁₁O₉

Molecular Weight: 751.87 g/mol

Structure: Synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin

Overview

Selank is a synthetic peptide developed from tuftsin, a naturally occurring immunomodulatory peptide involved in immune system signaling. Through structural modification, Selank exhibits enhanced stability and prolonged biological activity while retaining interactions with neurobiological and immunological pathways.

The peptide is widely studied in research involving neurotransmitter regulation, neuropeptide signaling, stress-response mechanisms, cognitive function, and neuroimmune interactions.

Mechanism of Action

Selank appears to exert modulatory effects across multiple neurological and immunological systems:

• Neurotransmitter Regulation
  • Influences signaling pathways associated with GABAergic activity
  • Modulates communication within central nervous system networks
• Neuropeptide Signaling
  • Interacts with endogenous peptide-regulated pathways
  • Influences neurochemical balance and neuronal communication
• Neuroimmune Activity
  • Derived from a peptide involved in immune regulation
  • Studied for interactions between immune and neurological signaling systems
• Stress Response Modulation
  • Investigated for effects on physiological adaptation pathways
  • Associated with regulation of stress-related neurochemical responses

The peptide’s biological activity appears to involve broad neuromodulatory mechanisms rather than direct activation of a single receptor target.

Pharmacokinetic Characteristics

• Synthetic heptapeptide structure
• Improved stability relative to endogenous tuftsin
• Subject to normal peptide degradation pathways
• Demonstrates activity within neurobiological signaling systems

Structural Characteristics

Selank is composed of the amino acid sequence:

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Key features include:

• Derived from the endogenous peptide tuftsin
• Seven-amino acid structure
• Water-soluble peptide architecture
• Designed for enhanced biological stability

Research Applications

Selank is commonly studied in research involving:

• Neurotransmitter signaling
• Neuropeptide biology
• Neuroimmune interactions
• Cognitive function research
• Stress-response mechanisms
• Central nervous system regulation

It remains a valuable research tool for investigating the relationship between neurological and immunological signaling pathways.

Handling & Stability

• Typically supplied as a lyophilized powder
• Requires reconstitution with a suitable sterile solvent prior to use
• Store at -20°C or below for long-term stability
• Protect from excessive heat, moisture, and prolonged light exposure
• Avoid repeated freeze-thaw cycles

Note

This material is intended for laboratory research use only and is not approved for human or veterinary applications.