Semax

Semax

Synonym: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)

CAS Number: 80714-61-0

Molecular Formula: C₃₇H₅₁N₉O₁₀

Molecular Weight: 813.86 g/mol

Structure: Synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-10)

Overview

Semax is a synthetic heptapeptide developed from the biologically active region of adrenocorticotropic hormone (ACTH). Structural modifications were introduced to enhance stability and prolong biological activity while eliminating hormonal effects associated with the parent molecule.

The peptide is widely studied in research involving neurotransmitter regulation, neurotrophic signaling, cognitive processes, neuroplasticity, and central nervous system function.

Mechanism of Action

Semax appears to influence multiple neurological signaling pathways:

• Neurotrophic Signaling
  • Associated with modulation of brain-derived neurotrophic factor (BDNF) pathways
  • Studied for its role in neuronal maintenance and plasticity
• Neurotransmitter Regulation
  • Influences signaling systems involving dopamine, serotonin, and related neurotransmitters
  • Modulates communication within central nervous system networks
• Neuroplasticity
  • Investigated for effects on neuronal adaptation and signaling efficiency
  • Associated with cellular pathways involved in learning and memory processes
• Stress Response Biology
  • Studied for interactions with physiological adaptation mechanisms
  • May influence neurochemical responses to environmental stressors

The peptide functions through broad neuromodulatory activity rather than direct activation of a single receptor system.

Pharmacokinetic Characteristics

• Synthetic heptapeptide structure
• Enhanced stability compared to endogenous ACTH fragments
• Subject to normal peptide degradation pathways
• Demonstrates activity within central nervous system signaling networks

Structural Characteristics

Semax consists of the amino acid sequence:

Met-Glu-His-Phe-Pro-Gly-Pro

Key features include:

• Derived from ACTH (4-10)
• Seven-amino acid structure
• Water-soluble peptide architecture
• Designed to retain neurobiological activity while minimizing endocrine effects

Research Applications

Semax is commonly studied in research involving:

• Neurotrophic signaling
• Cognitive function
• Neuroplasticity
• Neurotransmitter regulation
• Learning and memory research
• Central nervous system biology

It remains a valuable research tool for investigating mechanisms involved in neuronal communication and cognitive performance.

Handling & Stability

• Typically supplied as a lyophilized powder
• Requires reconstitution with a suitable sterile solvent prior to use
• Store at -20°C or below for long-term stability
• Protect from excessive heat, moisture, and prolonged light exposure
• Avoid repeated freeze-thaw cycles

Note

This material is intended for laboratory research use only and is not approved for human or veterinary applications.